More than 5.2 million people in Tigray, Ethiopia, are in dire need of humanitarian support, including health care, due to the conflict that erupted at the end of 2020. The conflict has left thousands injured and traumatized and had a severe impact on the families’ lives and livelihoods. The spillover of the conflict into the neighboring regions of Afar and Amhara is significantly increasing humanitarian needs in the northern part of the country. Over 2.1 million people have been displaced and are living in crowded settings with limited access to water and sanitation infrastructure.Over half of the health facilities in Tigray are not operational. People are suffering from trauma and injuries, food insecurity and malnutrition, sexual and gender-based violence, communicable diseases such as malaria, cholera, as well as reduced access to treatment for non-communicable diseases and maternal and child health services. The conflict has also disrupted the COVID-19 response. Millions of people are facing acute food insecurity in the region, with over 400 000 people close to famine. Access to affected areas remains limited, making the scale-up of the health response difficult even as the population’s needs are growing, especially for children, women, and internally displaced people.As Global Health Cluster lead, WHO is coordinating with 23 partners in Tigray and neighboring areas to provide the affected populations with emergency health support, including on prevention, preparedness and response to disease outbreaks.